What is ProMed S?

ProMed S is a probiotic dietary supplement that contains three strains of probiotics that have been scientifically proven to be effective in promoting health: 

• Bifidobacterium animalis TA-1: Ability to reduce cholesterol level (Puttarat et al., 2021; Puttarat et al., 2023)

• Lactobacillus paracasei MSMC39-1: Effectively reduces inflammation, balances gut microbiota, and promotes skin health (Ladda et al., 2015; Ladda et al., 2021; Banjonjit et al., 2022; Sathikulpakdee et al., 2022; Ladda et al., 2023)

• Lactobacillus reuteri TF314: Promotes the production of good cholesterol (HDL) and supports cardiovascular health.

• Bifidobacterium animalis TA-1
This strain helps reduce cholesterol by producing the enzyme bile salt hydrolase (BSH), which breaks down bile salts. The liver produces bile salts from cholesterol, which are crucial for fat digestion. Bile salt breakdown reduces their absorption in the intestines, causing the body to use more cholesterol to produce new bile salts. This process ultimately leads to a reduction in blood cholesterol levels. (Puttarat et al., 2021; Puttarat et al., 2023)

• Lactobacillus paracasei MSMC39-1
This strain helps reduce inflammation by decreasing the production of TNF-α (tumor necrosis factor-alpha), a cytokine that plays a key role in triggering inflammatory processes. Excessive levels of TNF-α can lead to chronic inflammation, which is associated with various conditions such as colitis, alcoholic fatty liver disease, and gingivitis. (Ladda et al., 2015; Ladda et al., 2021; Banjonjit et al., 2022; Sathikulpakdee et al., 2022; Ladda et al., 2023)

• Lactobacillus reuteri TF314
This strain enhances the production of HDL cholesterol, which helps remove LDL cholesterol from the bloodstream. This probiotic can reduce the risk of cardiovascular diseases.

1. Promotes Digestive Health:
Helps balance gut microbiota, reducing bloating, constipation, and other digestive issues (Ladda et al., 2023).
2. Reduces Cholesterol Levels:
Lowers blood cholesterol levels and promotes the production of HDL cholesterol (Puttarat et al., 2023).
3. Reduces Inflammation:
Helps decrease inflammation in the body, reducing the risk of conditions such as inflammatory bowel disease and alcoholic hepatitis (Ladda et al., 2021; Banjonjit et al., 2022; Ladda et al., 2023).
4. Supports Skin Health:
Lactobacillus paracasei MSMC39-1 helps reduce skin issues like acne by decreasing inflammation and strengthening the skin's protective barrier (Sathikulpakdee et al., 2022).
5. Antioxidant Properties:
ProMed S helps reduce oxidative stress in cells, promoting overall health and lowering the risk of chronic diseases (Puttarat et al., 2021).

• High Cholesterol: By reducing cholesterol levels, it can help prevent heart disease and vascular disorders (Puttarat et al., 2023).

• Excessive Free Radicals: Through its ability to lower free radicals and boost antioxidants, it helps alleviate oxidative stress in cells and slows down cellular degeneration.

• Inflammatory Conditions: By lowering TNF-α levels, it aids in alleviating symptoms of conditions such as inflammatory bowel disease, alcoholic hepatitis, and gingivitis (Ladda et al., 2015; Ladda et al., 2021; Banjonjit et al., 2022; Ladda et al., 2023).
• Digestive Disorders: It helps relieve symptoms of gastritis and acid reflux by promoting a balanced stomach environment, reducing gastric acid production, and balancing gut microbiota.

Research has shown that hypercholesterolemic rats and rats induced with colitis using Dextran Sulfate Sodium (DSS-induced colitis) were administered Bifidobacterium animalis TA-1 and Lactobacillus paracasei MSMC39-1, respectively, to observe their effects on cholesterol levels, inflammation, and gut health.

The study revealed significant reductions in cholesterol levels and TNF-α levels, as well as improved gut microbiota health. These findings highlight the potential of these probiotics in managing hypercholesterolemia and inflammatory conditions (Puttarat et al., 2023; Ladda et al., 2023).

For best results, take one capsule of ProMed S daily on an empty stomach or 30 minutes before a meal. Consistency is key to maximizing the benefits of this probiotic dietary supplement.

Clinical studies confirm that the probiotics in ProMed S are safe, with no reported side effects. If you have any concerns, it is advisable to consult a healthcare provider before use.

• Puttarat, N., Ladda, B., Kasorn, A., Tanasupawat, S., & Taweechotipatr, M. (2021). Cholesterol-lowering activity and functional characterization of lactic acid bacteria isolated from traditional Thai foods for their potential used as probiotics. Songklanakarin Journal of Science and Technology, 43(5), 1283-1291.

• Puttarat, N., Kasorn, A., Vitheejongjaroen, P., Chantarangkul, C., Tangwattanachuleeporn, M., & Taweechotipatr, M. (2023). Beneficial Effects of Indigenous Probiotics in High-Cholesterol Diet-Induced Hypercholesterolemic Rats. Nutrients, 15(12), 2710. 

• Ladda, B., Theparee, T., Chimchang, J., Tanasupawat, S., & Taweechotipatr, M. (2015). In vitro modulation of tumor necrosis factor α production in THP-1 cells by lactic acid bacteria isolated from healthy human infants. Anaerobe, 33, 109–116.

• Ladda, B., Padungchaichot, P., Pradidarcheep, W., Kasorn, A., & Taweechotipatr, M. (2021) Anti-inflammatory effect of probiotic lactobacillus paracasei MSMC39-1 on alcohol-induced hepatitis in rats. Journal of Applied Pharmaceutical Science, 11(4), 45-56.

• Sathikulpakdee, S., Kanokrungsee, S., Vitheejongjaroen, P., Kamanamool, N., Udompataikul, M., & Taweechotipatr, M. (2022). Efficacy of probiotic-derived lotion from Lactobacillus paracasei MSMC39-1 in mild to moderate acne vulgaris, randomized controlled trial. Journal of Cosmetic Dermatology, 21(4), 5092-5097.

• Banjonjit, S., Taweechotipatr, M., & Rungsiyanont, S. (2022). Effect of probiotic Lactobacillus paracasei on tumor necrosis factor-alpha level in gingival crevicular fluid of patients undergoing impacted third molar removal. Journal of oral science, 64(3), 185–189.

• Ladda, B., Jantararussamee, C., Pradidarcheep, W., Kasorn, A., Matsathit, U., & Taweechotipatr, M. (2023). Anti-Inflammatory and Gut Microbiota Modulating Effects of Probiotic Lactobacillus paracasei MSMC39-1 on Dextran Sulfate Sodium-Induced Colitis in Rats. Nutrients, 15(6), 1388-1404.